Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin
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چکیده
منابع مشابه
Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro.
The anthracycline drugs are important for the treatment of a number of malignancies; however, their clinical use is associated with dose-dependent severe chronic cardiotoxicity. Although the mechanism for this side effect has not yet been identified, the alcohol metabolites formed during daunorubicin (DAUN) and doxorubicin (DOX) therapies have been implicated. The alcohol metabolites of DAUN an...
متن کاملDMD #20388 Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro
The anthracycline drugs are important for the treatment of a number of malignancies; however, their clinical use is associated with dose-dependent severe chronic cardiotoxicity. While the mechanism for this side effect has not yet been identified, the alcohol metabolites formed during DAUN and DOX therapies have been implicated. The alcohol metabolites of DAUN and DOX, DAUNol and DOXol, respect...
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The Centers for Medicare and Medicaid Services (CMS) has applied the sequestration cuts to oncology in a drastic manner that grossly amplifies the magnitude of an already-problematic 2% cut. While CMS claims it is “unaware of any authority” to exempt cancer drugs from the sequester cuts,[2] it is likely that the agency could have mitigated the impact. CMS used its discretion to apply the 2% seq...
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Adipocytes promote cancer progression and impair treatment, and have been shown to protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate whether this protection is mediated by changes in oxidative stress. Co-culture experiments showed that adipocytes protect ALL cells from oxidative stress induced by drugs or irradiation. We demonstrated that ALL cells induce...
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; Azospirillum spp. are endophytic bacteria with beneficial effects on cereals — effects partially attributed to gibberellin production by the microorganisms. Azospirillum lipoferum and Azospirillum brasilense inoculated to rice dy mutant reversed dwarfism in seedlings incubated with [17,17-H2]GA20 with formation of [17,17H2]GA1, showing the in vivo capacity to perform the 3 -hydroxylation. Whe...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2017
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-17-0338